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Fildena and Long-Term Use: What Studies Show

62 Fildena and Long Term Use What Studies Show 1

Millions of men worldwide suffer from erectile dysfunction (ED), and Fildena (sildenafil citrate) is one of the standard ways to treat it. Short-term success is one thing; however, the long-term safety and efficacy of a treatment become paramount since patients may need to undergo further treatment. Based on studies, this article presents the long-term use of Fildena from what we know. 

Long-Term Efficacy: Years of Benefit

According to clinical trials, sildenafil (the active agent of Fildena) has a long-lasting efficacy:

Satisfaction of Patients: In an open-label study spanning 4 years involving 979 men with ED, more than 94% indicated their satisfaction with the treatment each year and with the aid the treatment gave them in sexual performance.

Persistent Response: During the studies ranging from 36 to 52 weeks, 89-92% of the 1,008 investigated patients reported continued improvement with erection during the studies.

Dosage Stability: Most subjects favored an oral dose of 100 mg, and increasing the dose did not change effectiveness, allaying fears about tachyphylaxis (loss of reaction with repeated exposure).

These results indicate that the long-term effect of Fildena works through nitric oxide-mediated vasodilation, clearly sustained as long as patients consume it according to directions.

Side effects are usually mild and manageable.

Sildenafil’s prolonged use gives rise to mild side effects, mostly as expected:

  • Typical side effects include headache, flushing, dyspepsia, and asthma, which occur in about 10-15 percent of patients and generally resolve spontaneously.
  • Vision Recently, transient vision changes, such as seeing blue, were uncommon and were attributed to the inhibition of PDE5 in retinal cells. Nevertheless, it was not found to cause any persistent damage to the retina.
  • Cardiovascular Safety: Of 979 men who were followed up for 4 years, only 0.1% developed palpitations or tachycardia due to treatment, and there was no direct association of sildenafil with heart attacks.

Interestingly, the dropout rate due to side effects was surprisingly minimal–only 1.1% within 4 years-which translates to an indication of excellent tolerability.

Important Studies Addressing Long-Term Use:

1st Study

4-Year Open Label Study (2007): 979 Men With ED (12.2% Were Diabetic and 28.2% Had Hypertension). Mean: 58 Years.

Admired over the 4-year period were 420 doses on average, with 88% of patients preferring the 100 mg dose. Only 3.8% needed dose alteration for treatment-related side effects.

Bottom Line: No deficiencies were identified in effectiveness or tolerability in patients with other diseases as well.

Extension studies of 52 weeks 

Reported that 89% improved erections after a year, along with significant increases in sexual satisfaction and erection firmness.

Safety: The rate of adverse events was similar to that seen in shorter-term statistics, and the risk of cardiovascular disease was very low.

Diabetes and cardiovascular disease: Specific populations

Patients with diabetes: Smaller group studies have shown that sildenafil still works for men with diabetes, who are even more at risk of ED.

Hypertensive: no clinically significant interactions with hypertensive drugs, but exercise caution with nitrates.

Aging: sildenafil tolerates pretty well for people 65 and older, though starting very low (25 to 50 mg) may help minimize side effects.

Common Issues

The myth of tachyphylaxis: Studies show that the idea of diminishing returns is not the case. In 4 years, only 6.3% of people who quit taking the medication because of no improvement did so because of a lack of reaction. This was mostly attributed to psychological problems related to the disease worsening, and thus not related to drug resistance.

Heart Risks: Sildenafil does not increase the risk of myocardial attack. Stable cardiac patients should not be given PDE5 inhibitors until their condition has been stabilized.

Although most people resort to Fildena when they need it, research shows that daily low-dose regimens (such as 25 mg) can be safely used for years, even if this is not mentioned on the drug’s label.

Real-life advice to long-term users

Dosage: Follow the dosing regimen as prescribed by your doctor (25-100 mg); do not modify it on your own. 

Monitoring: To periodically check how the medicine works and how the heart is functioning.

Lifestyle Synergy: Fildena is more effective if supplemented with exercises, cessation of smoking, and management of body weight.

Counterfeit Risks: Only buy Fildena from retail pharmacies where licenses have been given to avoid being bamboozled into buying counterfeit products or goods not vetted for their quality.

This should be the end

Fildena has been known for treating erectile dysfunction (ED) today with optimum safety and efficacy. It will continue to be a perfect choice in the improvement of sexual health because of very high patient satisfaction, low dropout rates, and manageable side effects. However, since everybody reacts differently to drugs, consulting a physician, thus giving the best benefit and minimizing risks, should be undertaken.

In people who can read about using Fildena, the clear advice says that nowadays, long-term treatment can benefit health for a long time without compromising safety as long as it is done carefully and guided by a specialist.

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